Bottom line: At the beginning of sensor life, it might not be a good idea to only depend on sensor readings only. Also, probably not a good idea to change the Guardian sensor, infusion set and eat pizza close together!
Last night, I had what I would call a perfect storm where I replaced my sensor and infusion set and then ate pizza. Unfortunately, my sensor did not catch up with a sharp rise in blood sugar since it had not stabilized. I only caught the high sugar readings when I checked my meter Blood Glucose (BG) reading.